D3 pcoa
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Interactive taxonomic stacked bar charts.
In a recent publication (MacPherson al., (2018), Scientific Reports; PMID:30046129), we reported kinetics of gut microbiome community profiles.
BACKGROUND:
Clinical effects of antimicrobials and probiotics in combination have been reported, however, little is known about their impact on gut microbiota and its resistome.
OBJECTIVES:
In this study 16S rRNA gene amplicon, shotgun metagenomics sequencing and antibiotic resistance (ABR) microarray were used on fecal samples of 70 healthy participants, taken at four time points in probiotic (Lactobacillus rhamnosus R0011 and Lactobacillus helveticus R0052) and placebo groups to profile the gut bacterial microbiota and its resistome following administration of amoxicillin-clavulanic acid for one week.
HIGHLIGHTS:
Significant shifts in microbiota family composition caused by the antimicrobial in both groups that included decreases in the proportion of Lachnospiraceae, Coriobacteriaceae and unidentified Clostridiales; and notable increases for the proportion of Enterobacteriaceae, Bacteroidaceae and Porphyromonadaceae compared to baseline levels.
This interactive visualization shows the distribution of the top 20 most abundant bacterial taxa in the aforementionned experiment.
Use the mouse to hover bar charts to reveal relative abundance of selected taxon.
Click on the buttons and checkboxes to select/filter or sort the bar panels.
Click on legend boxes to sort the taxa bars according to their abundance.
Click on the bar panels to drag and drop panels.
Data source: PMID:30046129
Author: Julien Tremblay - <a href=https://jtremblay.github.io>jtremblay.github.io</a>
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